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Iron (Fe), an essential nutrient that carries oxygen, forms part
of the oxygen-carrying proteins hemoglobin in red blood cells and myoglobin
in muscle. It is also a necessary component of various enzymes. Body
iron is concentrated in the storage forms, ferritin and hemosiderin,
in bone marrow, liver and spleen. Body iron stores can usually be estimated
from the amount of ferritin protein in serum. Transferrin protein in
the blood transports and delivers iron to cells.
IMPORTANCE:
Its major function is to combine with protein and copper in making hemoglobin.
Hemoglobin transports oxygen in the blood from the lungs to the tissues
which need oxygen to maintain basic life functions. Iron builds up the
quality of the blood and increases resistance to stress and disease.
It is also necessary for the formation of myoglobin which is found only
in muscle tissue. Myoglobin supps oxygen to muscle cells for use in
the chemical reaction that results in muscle contraction. Iron also
prevent fatigue and promotes good skin tone.
DEFICIENCY SYMPTOMS:
May result in weakness, paleness of skin, constipation, anemia.
: Severe iron deficiency results in anemia with small, pale, red blood
cells that have a low hemoglobin concentration. Iron deficiency anemia
in pregnancy increases the risk of premature and low birth weight babies.
In young children, iron deficiency is associated with behavioral abnormalities
(such as reduced attention span) and reduced cognitive performance that
may not be fully reversible by iron replacement. In adults, iron deficiency
anemia impairs physical work capacity. In the US, severe iron deficiency
anemia is relatively rare. Impaired iron status is most common in 1-2
year-old children (9.3%), males aged 11-14 years old (4.1%) and females
15-44 years old (6.3-7.2%). This impairment reflects rapid growth or
menstrual iron loss and it is uncommon (2%) in other groups.
Diet recommendations:
The 1989 Recommended Dietary Allowance
U.S. RDA FOR IRON |
babies:
birth to 6 months
6 months to 1 year |
6 mg per day
10 mg per day |
children:
1 to 10 years |
10 mg per day |
men and boys:
11 to 18 years
19 to 51+ years |
12 mg per day
10 mg per day |
women and girls:
11 to 50 years
51+ years |
15 mg per day
10 mg per day |
pregnant women |
30 mg per day |
nursing mothers |
15 mg per day |
Food sources:
In the US, grain products are a principal source of dietary iron, followed
by meat, poultry and fish, vegetables, legumes, nuts and soy. Red meat
is a rich source of iron that is well absorbed. Heme iron (about 40%
of the iron in meat, poultry, or fish, and 7-12% of the iron in US diets)
is 15-45% absorbed, depending on iron stores. (Individuals with low
iron stores compensate by absorbing more iron). Nonheme iron, the remaining
majority of dietary iron, is 1-15% absorbed. Absorption is dependent
on iron stores and absorption enhancers (e.g., ascorbic acid, an unidentified
factor in meat, poultry and fish) or inhibitors (e.g., phytic acid in
whole grains and legumes, polyphenols in tea, coffee, or red wine, calcium
in dairy products or supplements) eaten concurrently. U.S refined grain
products are routinely enriched with iron. Iron-fortified formula or
cereals are useful in preventing iron deficiency in infants.
Toxicity:
Iron supplements intended for other household members are the most common
cause of pediatric poisoning deaths in the US. In populations of European
origin, approximately 1 in 300 people have hemochromatosis, a genetic
abnormality of excessive iron stores. Ten percent of these populations
carry a gene (are heterozygous) for hemochromatosis. Researchers are
testing hypotheses that high iron stores may increase the risk of chronic
diseases, such as cancer and heart disease, through oxidative mechanisms.
For further information:
Institute of Medicine, Food and Nutrition Board (1993) Iron Deficiency
Anemia: Recommended Guidelines for the Prevention, Detection, and Management
Among U.S. Children and Women of Childbearing Age. National Academy
Press, Washington, DC.
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